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Plymouth has a post-war shopping area in the city centre with substantial pedestrianisation. At the west end of the zone inside a grade II listed building is the Pannier Market that was completed in 1959 pannier meaning "basket" from French, so it translates as "basket market". In terms of retail floorspace, Plymouth is ranked in the top five in the South West, and 29th nationally. Plymouth was one of the first ten British cities to trial the new Business Improvement District initiative. The Tinside Pool is situated at the foot of the Hoe and became a grade II listed building in 1998 before being restored to its 1930s look for £3.4 million.

Plymouth Council is currently undertaking a project of urban redevelopment called the "Vision for Plymouth" launched by the architect David Mackay and backed by Plymouth City Council. Its projects range from shopping centres, a cruise terminal, a boulevard and to increase the population to 300,000 and build 33,000 dwellings.

In 2004 the old Drake Circus shopping centre and Charles Cross car park were demolished and replaced by the latest Drake Circus Shopping Centre, which opened in October 2006. It received negative feedback before opening when David Mackay said it was already "ten years out of date". In contrast, the Theatre Royal's production and education centre, TR2, which was built on wasteland at Cattedown, was a runner-up for the RIBA Stirling Prize for Architecture in 2003.

There is a project involving the future relocation of Plymouth City Council's headquarters, the civic centre, to the current location of the Bretonside bus station; it would involve both the bus station and civic centre being demolished and a rebuilt together at the location with the land from the civic centre being sold off. Other suggestions include the demolition of the Plymouth Pavilions entertainment arena to create a canal "boulevard" linking Millbay to the city centre. Millbay is being regenerated with mixed residential, retail and office space alongside the ferry port.

The A38 dual-carriageway runs from east to west across the north of the city. Heading east, it connects Plymouth to the M5 motorway about 40 miles (64 km) away near Exeter; and heading west it connects Cornwall and Devon via the Tamar Bridge. Regular bus services are provided by Plymouth Citybus, First Group and Target Travel. There are three Park and ride services located at Milehouse, Coypool (Plympton) and George Junction (Plymouth City Airport), which are operated by First Group.

A regular international ferry service provided by Brittany Ferries operates from Millbay taking cars and foot passengers directly to France (Roscoff) and Spain (Santander) on the three ferries, MV Armorique, MV Bretagne and MV Pont-Aven. There is a passenger ferry between Stonehouse and the Cornish hamlet of Cremyll, which is believed to have operated continuously since 1204. There is also a pedestrian ferry from the Mayflower Steps to Mount Batten, and an alternative to using the Tamar Bridge via the Torpoint Ferry (vehicle and pedestrian) across the River Tamar.

The city's airport is Plymouth City Airport about 4 miles (6.4 km) north of the city centre. The airport is home to the local airline Air Southwest, which operates flights across the British Isles and France. In June 2003 a report by the South West RDA was published looking at the future of aviation in the south-west and the possible closure of airports. It concluded that the best option for the south-west was to close Plymouth City Airport and expand Exeter International Airport and Newquay Cornwall Airport, although it did conclude that this was not the best option for Plymouth.

Plymouth railway station, which opened in 1877, is managed by First Great Western and also sees trains on the CrossCountry and South West Trains networks. Smaller stations are served by local trains on the Tamar Valley Line and Cornish Main Line. First Great Western have come under fire recently, due to widespread rail service cuts across the south-west, which affect Plymouth greatly. Three MPs from the three main political parties in the region have lobbied that the train services are vital to its economy.